Cardiac Postconditioning: An Additional Therapy to Limit Cell Death Following Myocardial Infarction

Effects of Postconditioning, Preconditioning and Perfusion of L-carnitine During Whole Period of Ischemia/ Reperfusion on Cardiac Hemodynamic Functions and Myocardial Infarction Size in Isolated Rat Heart

Signalling pathways in ischaemic postconditioning.

Coronary heart disease (CHD) is the leading cause of death globally. Following an acute coronary artery occlusion, timely myocardial reperfusion using either primary percutaneous coronary intervention (PCI) or thrombolytic therapy remains the most effective treatment strategy for reducing myocardial infarct size, preventing left ventricular remodelling, preserving left ventricular systolic func...

Transplantation of Cardiogenic Pre-Differentiated Autologous Adipose-Derived Mesenchymal Stem Cells Induced by Mechanical Loading Improves Cardiac Function Following Acute Myocardial Infarction in Rabbit Model

Objective- Investigate myocardial performance after autologous adipose-derived (ASCs) mesenchymal stem cell differentiated under equiaxial cyclic strain, transplantation in rabbits with acute myocardial infarction (AMI). Design- Prospective, randomized experimental study Animals- 20 New Zealand White rabbits (2-3 kg) P...

The winding road to cardioprotection

Over the past two decades, the mortality from acute myocardial infarction (AMI) has been reduced dramatically. Timely reperfusion is the most powerful intervention for limiting infarct size, alongside antiplatelet, antithrombotic and anti-ischemic therapies. Paradoxically, reperfusion itself can also exacerbate myocardial injury, so called ‘‘reperfusion injury’’, which can cause additional card...

Prediction of long-term cardiac events by 123I-MIBG imaging after acute myocardial infarction and reperfusion therapy

Objective(s): In heart failure, the heart-to-mediastinum (H/M) ratio of the delayed image and washout rate (WR) are well-known as a powerful cardiac event predictors. H/M ratio quantifies the accumulation rate of MIBG in the myocardium and WR quantifies reduction of meta-iodobenzylguanidine (MIBG) accumulation in the heart from the early planar image to the delayed pla...